The Vehicle, Fall 1985

Vol. 27, No. 1 Table of Contents Satchel AssMichael D. Smithpage 3 PhotoDoug Andersonpage 7 CounselingChristy Dunphypage 8 Grave SiteJay D. Fiskpage 8 Sight-Seeing Outside PhoenixBob Zordanipage 9 PerformanceDan Von Holtenpage 10 NightmareKandy Bellpage 10 Photo (The Loft)Lawrence McGownpage 11 LaboringJanet Gracepage 12 Blood DonorDan Von Holtenpage 13 Photo (Pier)Lawrence McGownpage 14 ExamplesChristopher Albinpage 14 Three PoemsPatrick Peterspage 15 Sometimes I Dream in Cotton CandyKathy Graypage 16 One Day While BoatingF. Link Rapierpage 17 DepartureBob Zordanipage 17 140 Print That\u27s Life Peter Dowlingpage 18 Photo (Around the Bend)Mike Freckerpage 20 Light ConversationDan Hintzpage 22 She Waits For the WorldJim Harrispage 22 HoneyKathy Graypage 23 Photo AlbumPatrick Peterspage 24 Photo (Stairs)Lawrence McGownpage 25 Fallen From Grace to SaturdayF. Link Rapierpage 26 Post MortemF. Link Rapierpage 27 ConfessionJohn Kayserpage 27 Child\u27s PlayChristopher Albinpage 27 Seeking A Friend\u27s Advice on DietingKathy Graypage 28 PhotoDoug Andersonpage 28 She Came Back to MeJim Harrispage 29 Farm BoyDiana Winsonpage 30 DilemmaJanet Wilhelmpage 31 In a Rock or StoneRichard Donnellypage 32 In November He Came To MeJean Kover Chandlerpage 33 EndingChristy Dunphypage 34 The Honor GradEddie Simpsonpage 35 Photo (Thirst)Mike Freckerpage 40https://thekeep.eiu.edu/vehicle/1046/thumbnail.jp

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Characterisation of the plasmin receptor of Streptococcus uberis

SIGLEAvailable from British Library Document Supply Centre- DSC:DXN060370 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Remunerative railways for new countries; with some account of the first railway in China.

Mode of access: Internet

The Activation of Bovine Plasminogen by PauA Is Not Required for Virulence of Streptococcus uberis

A mutant of Streptococcus uberis carrying a single copy of ISS1 within pauA was unable to activate bovine plasminogen. Contrary to a hypothesis postulated previously, this mutation did not alter the ability of the bacterium to grow in milk or to infect the lactating bovine mammary gland

Oxytocin-enhanced group therapy for methamphetamine use disorder: Randomized controlled trial.

BackgroundMethamphetamine (METH) use is a public health crisis that disproportionately affects men who have sex with men (MSM). There are currently no FDA-approved pharmacological interventions to treat methamphetamine use disorder (MUD). MUD is associated with social impairments and extremely high treatment attrition rates. Administration of oxytocin, a neuropeptide involved in social attachment, may be a novel approach to addressing these issues. Moreover, oxytocin administration has shown promise for reducing METH-related addictive behavior in animal models, but has not yet been investigated in clinical trials for MUD. Last, oxytocin is known to modulate stress responsivity via regulation of the autonomic nervous system, which is dysregulated in METH users. We hypothesize that oxytocin, in combination with group psychotherapy, will increase treatment engagement, reduce addiction behavior, and mitigate stress hyperreactivity.MethodsThis is a randomized, double blind trial of oxytocin 40-IU (n = 24) or placebo (n = 24) administered intranasally prior to each of six weekly motivational interviewing group therapy (MIGT) sessions for MUD in MSM.Primary outcome(a) session attendance.Secondary outcomes(b) group cohesion, (c) anxiety, (d) METH craving, (e) METH use, and (f) in-session cardiac physiology.ResultsParticipants receiving oxytocin had significantly higher group therapy attendance than those receiving placebo, OR 3.26, 95% CI [1.27-8.41], p = .014. There was a small effect of oxytocin on group cohension, but not anxiety or craving. METH use did not change over the six-week MIGT course in either treatment arm. Participants receiving oxytocin had lower average heart rates during MIGT sessions and higher heart rate variability. There were positive main effects of MIGT over Time regardless of study drug.ConclusionsThis evidence, and the lack of any serious adverse events, suggests that oxytocin may safely increase treatment attendance. One possible mechanism by which it may do so is its modulation of the autonomic nervous system. Further investigation is warranted

Challenges Facing Investment Disputes: Reconsidering Dispute Resolution in International Investment Agreements

This volume brings together significant contributions from leading voices in academia, the legal profession and government on the increasingly important topic of international investment and the legal system in which it operates. With the burgeoning size of international capital flows matched only by an explosion in international agreements intending to regulate the field, there is increasing potential for incoherence amongst and between treaties and arbitral decisions. Appeals Mechanism in International Investment Disputes compiles, compares and contrasts the analysis and arguments of the leading scholars, practitioners and government officials on the future of the international investment law regime. Its special emphasis is on the question of an appellate body for international investment disputes. The authors also seek ways to streamline and improve the system, channeling the benefits of free trade and investment flows to people in both the developing and emerging markets. The Appendices provide readers with extensive background material to place the chapters into context. Selected sections include concise commentaries to further illuminate the timely themes covered by the chapters. The volume is singular in its success at bringing together so many exceptional individuals on a question of growing import-how to improve the international law regime to increase prosperity and further global development. If a reader wants to know what the influential voices in international law are saying right now, and in a concise and readable format, this is the publication to have.https://digitalcommons.wcl.american.edu/facsch_bk_contributions/1389/thumbnail.jp

Challenges Facing Investment Disputes: Reconsidering Dispute Resolution in International Investment Agreements

This volume brings together significant contributions from leading voices in academia, the legal profession and government on the increasingly important topic of international investment and the legal system in which it operates. With the burgeoning size of international capital flows matched only by an explosion in international agreements intending to regulate the field, there is increasing potential for incoherence amongst and between treaties and arbitral decisions. Appeals Mechanism in International Investment Disputes compiles, compares and contrasts the analysis and arguments of the leading scholars, practitioners and government officials on the future of the international investment law regime. Its special emphasis is on the question of an appellate body for international investment disputes. The authors also seek ways to streamline and improve the system, channeling the benefits of free trade and investment flows to people in both the developing and emerging markets. The Appendices provide readers with extensive background material to place the chapters into context. Selected sections include concise commentaries to further illuminate the timely themes covered by the chapters. The volume is singular in its success at bringing together so many exceptional individuals on a question of growing import-how to improve the international law regime to increase prosperity and further global development. If a reader wants to know what the influential voices in international law are saying right now, and in a concise and readable format, this is the publication to have.https://digitalcommons.wcl.american.edu/facsch_bk_contributions/1389/thumbnail.jp

The Vehicle, Fall 1985

Vol. 27, No. 1 Table of Contents Satchel AssMichael D. Smithpage 3 PhotoDoug Andersonpage 7 CounselingChristy Dunphypage 8 Grave SiteJay D. Fiskpage 8 Sight-Seeing Outside PhoenixBob Zordanipage 9 PerformanceDan Von Holtenpage 10 NightmareKandy Bellpage 10 Photo (The Loft)Lawrence McGownpage 11 LaboringJanet Gracepage 12 Blood DonorDan Von Holtenpage 13 Photo (Pier)Lawrence McGownpage 14 ExamplesChristopher Albinpage 14 Three PoemsPatrick Peterspage 15 Sometimes I Dream in Cotton CandyKathy Graypage 16 One Day While BoatingF. Link Rapierpage 17 DepartureBob Zordanipage 17 140 Print That\u27s Life Peter Dowlingpage 18 Photo (Around the Bend)Mike Freckerpage 20 Light ConversationDan Hintzpage 22 She Waits For the WorldJim Harrispage 22 HoneyKathy Graypage 23 Photo AlbumPatrick Peterspage 24 Photo (Stairs)Lawrence McGownpage 25 Fallen From Grace to SaturdayF. Link Rapierpage 26 Post MortemF. Link Rapierpage 27 ConfessionJohn Kayserpage 27 Child\u27s PlayChristopher Albinpage 27 Seeking A Friend\u27s Advice on DietingKathy Graypage 28 PhotoDoug Andersonpage 28 She Came Back to MeJim Harrispage 29 Farm BoyDiana Winsonpage 30 DilemmaJanet Wilhelmpage 31 In a Rock or StoneRichard Donnellypage 32 In November He Came To MeJean Kover Chandlerpage 33 EndingChristy Dunphypage 34 The Honor GradEddie Simpsonpage 35 Photo (Thirst)Mike Freckerpage 40https://thekeep.eiu.edu/vehicle/1046/thumbnail.jp